Y-27632 Dihydrochloride

A potent ROCK inhibitor

Cat. No.: AUR11260

CAS Number: 129830-38-2

Documents:

SizePrice

1 g

$ 750

Tags Y-27632 dihydrochloride Y27632 ROK inhibitor Rho kinase inhibitor CAS#129830-38-2 129830-38-2

Alternate Names

4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide, dihydrochloride

Appearance

White solid

Formulation

n/a

CAS Number

129830-38-2

Molecular Formula

C14H21N3O.2HCl

Molecular Weight

320.26

Purity

≥98% by HPLC

Solubility

DMSO (>30 mg/ml) or Water (>30 mg/ml)

Handling

Protect from air and moisture

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

MFCD03490488

PubChem CID

9901617

SMILES

CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

InChI

InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1

InChI key

IDDDVXIUIXWAGJ-DDSAHXNVSA-N

Y-27632 dihydrochloride is a selective ROCK inhibitor (Ki values are 0.14-0.22, 0.3, 25, 26 and > 250 μM for ROCK1 (p160 ROCK), ROCK2, PKA, PKC and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation