Cdk2 Inhibitor III, CVT-313

A potent Cdk2 inhibitor

Cat. No.: AUR11360

CAS Number: 199986-75-9

Documents:

SizePrice

5 mg

$ 175

Tags CVT-313 cdk2 inhibitor ATP-competitive CAS#199986-75-9 199986-75-9 Auroramedbiochem

Alternate Names

2-[2-hydroxyethyl-[6-[(4-methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]ethanol; CVT-313

Appearance

Off-white solid

Formulation

N/A

CAS Number

199986-75-9

Molecular Formula

C20H28N6O3

Molecular Weight

400.47

Purity

≥95% by HPLC

Solubility

DMSO (~10 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

6918386

SMILES

CC(C)N1C=NC2=C(N=C(N=C21)N(CCO)CCO)NCC3=CC=C(C=C3)OC

InChI

InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)

InChI key

NQVIIUBWMBHLOZ-UHFFFAOYSA-N

CVT-313 is a potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 >1.25 mM for MAPK, PKA, and PKC).