Dasatinib (BMS-354825, Sprycel)

A multikinase inhibitor

Cat. No.: AUR10294

CAS Number: 302962-49-8

Documents:

SizePrice

1 g

$ 165

Tags Dasatinib BMS-354825 302962-49-8 302962498 multikinase inhibitor Auroramedbiochem

Alternate Names

BMS-354825, Sprycel

Appearance

White to off-white solid

Formulation

N/A

CAS Number

302962-49-8

Molecular Formula

C₂₂H₂₆ClN₇O₂S

Molecular Weight

488.01

Purity

≥98% by HPLC

Solubility

DMSO (>45mg/ml)

Handling

Protect from light and air

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

Shelf life

24 months

MDL number

MFCD11046566

PubChem CID

3062316

SMILES

CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO

InChI

InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChI key

ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Dasatinib is a multi-kinase inhibitor with potent activity against BCR–ABL kinase (IC₅₀ <1 nM) and Src family kinases (IC₅₀ = 0.2–1.1 nM). Dasatinib also inhibits Lyn (IC₅₀ = 8.5 nM) and Src (IC₅₀ = 3.0 nM) kinase activities in vitro using 0.1 mg/mL poly (Glu4-Tyr) as the substrate.