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WYE-354

WYE-354

A mTORC1 and mTORC2 inhibitor

Cat. No.: AUR11377

CAS Number: 1062169-56-5

Documents:              

SizePrice

$ 675 
  
Tags WYE-354 WYE354 mTOR inhibitpor mTORC1 mTOTRC2 inhibitor CAS#1062169-56-5 1062169-56-5

Alternate Names

methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Appearance

White solid

Formulation

n/a

CAS Number

1062169-56-5

Molecular Formula

C24H29N7O5

Molecular Weight

495.5

Purity

>98% by HPLC

Solubility

DMSO (50 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

gel pack

Shelf life

24 months

MDL number

n/a

PubChem CID

44219749

SMILES

COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5

InChI

InChI=1S/C24H29N7O5/c1-34-23(32)26-17-5-3-16(4-6-17)20-27-21(29-11-13-36-14-12-29)19-15-25-31(22(19)28-20)18-7-9-30(10-8-18)24(33)35-2/h3-6,15,18H,7-14H2,1-2H3,(H,26,32)

InChI key

IMXHGCRIEAKIBU-UHFFFAOYSA-N

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2.

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