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Wortmannin

Wortmannin

A phosphatidylinositol 3-kinase (PI3-K) inhibitor

Cat. No.: AUR11243

CAS Number: 19545-26-7

Documents:              

SizePrice

$ 475 
  
Tags Wortmannin KY12420 PI3 kinase inhibitor PI3K inhibitor CAS#19545-26-7 19545-26-7 Auroramedbiochem

Alternate Names

KY12420

Appearance

White to off-white solid

Formulation

n/a

CAS Number

19545-26-7

Molecular Formula

C23H24O8

Molecular Weight

428.4

Purity

>98% by HPLC

Solubility

DMSO (~25 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

gel pack

Shelf life

24 months

MDL number

MFCD00133927

PubChem CID

312145

SMILES

CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C

InChI

InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChI key

QDLHCMPXEPAAMD-QAIWCSMKSA-N

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines.

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