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U0126-EtOH

U0126-EtOH

A potent MEK inhibitor

Cat. No.: AUR11170

CAS Number: 1173097-76-1

Documents:              

SizePrice

$ 475 
  
Tags U0126 U 0126 109511-58-2 U0126-EtOH MEK inhubitor CAS#1173097-76-1 1173097-76-1 auroramedbiochem

Alternate Names

1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene; ethanol

Appearance

White to off-white solid

Formulation

n/a

CAS Number

1173097-76-1

Molecular Formula

C18H16N6S2.C2H6O

Molecular Weight

426.56

Purity

≥98% by HPLC

Solubility

DMSO (>50 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

gel pack

Shelf life

24 months

MDL number

n/a

PubChem CID

16220066

SMILES

CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N

InChI

InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;

InChI key

CFQULUVMLGZVAF-OYJDLGDISA-N

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays. It displays 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.

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