Thymidylate Kinase Inhibitor, YMU1

A Thymidylate kinase (TMPK) inhibitor

Cat. No.: AUR11091

CAS Number: 902589-96-2

Documents:

SizePrice

25 mg

$ 275

Tags YMU1 Thymidylate kinase inhibitor TMPK inhuibitor CAS#902589-96-2 902589-96-2 Aurora medbiochem

Alternate Names

Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate; TMPK Inhibitor; YMU1

Appearance

White solid

Formulation

n/a

CAS Number

902589-96-2

Molecular Formula

C17H22N4O4S

Molecular Weight

378.45

Purity

≥98% by HPLC

Solubility

DMSO (>3 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

n/a

PubChem CID

49878590

SMILES

CCOC(=O)N1CCN(CC1)C(=O)CN2C(=O)C3=C(S2)N=C(C=C3C)C

InChI

InChI=1S/C17H22N4O4S/c1-4-25-17(24)20-7-5-19(6-8-20)13(22)10-21-16(23)14-11(2)9-12(3)18-15(14)26-21/h9H,4-8,10H2,1-3H3

InChI key

XXUFNNVFZFVKGP-UHFFFAOYSA-N

YMU1 is a pyridineisothiazolone compound that acts as a potent, reversible, and ATP-competitive inhibitor of human Thymidylate kinase (TMPK) (IC50 = 610 nM; Ki = 180 nM). Does not affect the activity of Thymidine kinase 1 (TK1) (IC50 >10 µM

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