PDK1 Inhibitor II

A potent PDK inhibitor

Cat. No.: AUR10783

CAS Number: 850717-64-5

Documents:

SizePrice

100 mg

$ 895

Tags PDK inhibitor II BX517 BX-517 ATP-competitive CAS#850717-64-5 850717-64-5 Auroramedbiochem

Alternate Names

[(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]urea; BX-517

Appearance

Dark brown solid

Formulation

N/A

CAS Number

850717-64-5

Molecular Formula

C15H14N4O2

Molecular Weight

282.3

Purity

≥95% by HPLC

Solubility

DMSO (25 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

11161844

SMILES

CC(=C1C2=C(C=CC(=C2)NC(=O)N)NC1=O)C3=CC=CN3

InChI

InChI=1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-

InChI key

DFURSNCTQGJRRX-JYRVWZFOSA-N

PDK Inhibitor II is a potent, ATP site-targeting PDK1 inhibitor (IC50 = 6 nM) and effectively suppresses cellular Akt Thr308 phosphorylation level in PC-3 cultures (IC50 ≤1 µM), while affecting PKA (IC50 = 1.6 µM) and 7 other kinases (IC50 ≥600 nM) only at much higher concentrations.