TRPV4 Antagonist II, HC-067047

A potent TRPV4 antagonist

Cat. No.: AUR11116

CAS Number: 883031-03-6

Documents:

SizePrice

50 mg

$ 625

Tags HC 067047 HC-067047 TRPV4 antagonist CAS#883031-03-6 883031-03-6 Auroramedbiochem

Alternate Names

2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide

Appearance

White solid

Formulation

n/a

CAS Number

883031-03-6

Molecular Formula

C26H28F3N3O2

Molecular Weight

471.5

Purity

≥98% by HPLC

Solubility

DMSO 15 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

MFCD01571257

PubChem CID

2742550

SMILES

CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F

InChI

InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)

InChI key

NCZYSQOTAYFTNM-UHFFFAOYSA-N

HC 067047 is a selective and potent TRPV4 antagonist. This compound has been found to reversibly inhibit currents through mouse, human and rat TRPV4 orthologs. Additional data suggests that HC 067047 inhibits the endogenous TRPV4-mediated response to 4-αPDH.