STAT3/STAT5 Dual Inhibitor, SH-4-54

A potent STAT inhibitor

Cat. No.: AUR11019

CAS Number: 1456632-40-8

Documents:

SizePrice

100 mg

$ 825

Tags SH-4-54 SH4-54 Stat3 Stat5 dual inhibitor CAS#1456632-40-8 1456632-40-8 Auroramedbiochem

Alternate Names

4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid

Appearance

White solid

Formulation

N/A

CAS Number

1456632-40-8

Molecular Formula

C29H27F5N2O5S

Molecular Weight

610.6

Purity

>94% by HPLC

Solubility

DMSO (>100 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

72188643

SMILES

CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F

InChI

InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39)

InChI key

VFPYGNNOSJWBHF-UHFFFAOYSA-N

SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.

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