SGI-1027

A DNA methyltransferase inhibitor

Cat. No.: AUR11313

CAS Number: 1020149-73-8

Documents:

SizePrice

100 mg

$ 975

Tags SGI-1027 SGI1027 SGI 1027 DNMT inhibitor DNA methyltransferases inhibitor CAS#1020149-73-8 1020149-73-8 Auroramedbiochem

Alternate Names

N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide

Appearance

White solid

Formulation

N/A

CAS Number

1020149-73-8

Molecular Formula

C27H23N7O

Molecular Weight

461.53

Purity

≥88% by TLC

Solubility

DMSO (50 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

MFCD27937047

PubChem CID

24858111

SMILES

CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54

InChI

InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)

InChI key

QSYLKMKIVWJAAK-UHFFFAOYSA-N

SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 μM, respectively, with Poly(dI-dC) as the substrate).