Puromycin dihydrochloride

A protein synthesis inhibitor

Cat. No.: AUR10843

CAS Number: 58-58-2

Documents:

SizePrice

100 mg

$ 275

Tags Puromycin dihydrochloride Puromycin protein synthesis inhibitor antibiotic CAS#58-58-2 58-58-2 Auroramedbiochem

Alternate Names

2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride; Puromycin hydrochloride

Appearance

White to off-white solid

Formulation

N/A

CAS Number

58-58-2

Molecular Formula

C22H29N7O5 · 2HCl

Molecular Weight

544.43

Purity

≥98% by HPLC

Solubility

n/a

Handling

Protect from air and moisture

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

gel pack

Shelf life

24 months

MDL number

MFCD00012691

PubChem CID

443311

SMILES

CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl

InChI

InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1

InChI key

MKSVFGKWZLUTTO-FZFAUISWSA-N

Puromycin dihydrochloride is a nucleoside antibiotic. It inhibits protein synthesis by disrupting peptide transfer on ribosomes causing premature chain termination during translation. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to puromycin is conferred by the puromycin N-acetyl-transferase gene (pac) from Streptomyces. Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations.

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