PTPase Inhibitor V, PHPS1
A Shp-2 inhibitor
Cat. No.: AUR10833
CAS Number: 314291-83-3
Documents:
$ 155
Alternate Names
4-[[5-(4-nitrophenyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]diazenyl]benzenesulfonic acid
Appearance
Orange-brown to reddish solid
Formulation
N/A
CAS Number
314291-83-3
Molecular Formula
C21H15N5O6S
Molecular Weight
465.4
Purity
≥95% by LCMS
Solubility
DMSO (>25 mg/ml)
Handling
Protect from air and light
Country of origin
USA
Storage temperature
+2 to +8 ◦C
Shipping Condition
RT
Shelf life
24 months
MDL number
PubChem CID
3109390
SMILES
C1=CC=C(C=C1)N2C(=O)C(=C(N2)C3=CC=C(C=C3)[N+](=O)[O-])N=NC4=CC=C(C=C4)S(=O)(=O)O
InChI
InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,24H,(H,30,31,32)
InChI key
IYPHPQODKSHEHV-UHFFFAOYSA-N
PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively)
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