NSC-697923

A potent UBE2N (Ubc13) inhibitor

Cat. No.: AUR11172

CAS Number: 343351-67-7

Documents:

SizePrice

25 mg

$ 205

Tags NSC-697923 NSC697923 UBE2N (Ubc13). Inhibitor CAS#343351-67-7 343351-67-7 Aurora Medbiochem

Alternate Names

2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran

Appearance

Off-white solid

Formulation

N/A

CAS Number

343351-67-7

Molecular Formula

C11H9NO5S

Molecular Weight

267.26

Purity

≥98% by HPLC

Solubility

DMSO (>25 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

394449

SMILES

CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]

InChI

InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3

InChI key

GAUHIPWCDXOLCZ-UHFFFAOYSA-N

NSC-697923 is a potent and selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines