Mitochondrial Division Inhibitor, mdivi-1

A selective inhibitor of dynamin GTPase

Cat. No.: AUR10632

CAS Number: 338967-87-6

Documents:

SizePrice

10 mg

$ 145

Tags Mitochondrial Division Inhibitor mdivi-1 Gtpases inhibitor CAS#338967-87-6 338967-87-6 Auroramedbiochem

Alternate Names

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one; mdivi-

Appearance

White solid

Formulation

N/A

CAS Number

338967-87-6

Molecular Formula

C15H10Cl2N2O2S

Molecular Weight

353.22

Purity

≥95% by HPLC

Solubility

DMSO (>30 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

Shelf life

24 months

MDL number

MFCD00974506

PubChem CID

3825829

SMILES

COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl

InChI

InChI=1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis..

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