IκB Ubiquitination Inhibitor, GS143

A β-TrCP1 ligase inhibitor

Cat. No.: AUR10454

CAS Number: 916232-21-8

Documents:

SizePrice

100 mg

$ 1375

Tags GS-143 GS143 GS 143 IκBα ubiquitination β-TrCP1 ligase inhuibitor CAS#916232-21-8 916232-21-8 Auroramedbiochem

Alternate Names

4-[(4E)-3-benzyl-4-[[5-(2-fluorophenyl)furan-2-yl]methylidene]-5-oxopyrazol-1-yl]benzoic acid; GS-143

Appearance

Dark red solid

Formulation

N/A

CAS Number

916232-21-8

Molecular Formula

C28H19FN2O4

Molecular Weight

466.5

Purity

>97% by HPLC

Solubility

DMSO (25 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

121513876

SMILES

C1=CC=C(C=C1)CC2=NN(C(=O)C2=CC3=CC=C(O3)C4=CC=CC=C4F)C5=CC=C(C=C5)C(=O)O

InChI

InChI=1S/C28H19FN2O4/c29-24-9-5-4-8-22(24)26-15-14-21(35-26)17-23-25(16-18-6-2-1-3-7-18)30-31(27(23)32)20-12-10-19(11-13-20)28(33)34/h1-15,17H,16H2,(H,33,34)/b23-17+

InChI key

IZPMWFSVTDOCDI-HAVVHWLPSA-N

GS 143 is a β-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.

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