HIF-2a Translation Inhibitor

HIF-2a translation inhibitor

Cat. No.: AUR10007

CAS Number: 882268-69-1

Documents:

SizePrice

100 mg

$ 975

Tags HIF-2α translation inhibitor HIF-2a CAS#882268-69-1 882268-69-1 Auroramedbiochem

Alternate Names

methyl 3-[(2E)-2-[cyano(methylsulfonyl)methylidene]hydrazinyl]thiophene-2-carboxylate

Appearance

Yellow solid

Formulation

N/A

CAS Number

882268-69-1

Molecular Formula

C9H9N3O4S2

Molecular Weight

287.3

Purity

>95% by LCMS

Solubility

DMSO

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

6375097

SMILES

COC(=O)C1=C(C=CS1)NN=C(C#N)S(=O)(=O)C

InChI

InChI=1S/C9H9N3O4S2/c1-16-9(13)8-6(3-4-17-8)11-12-7(5-10)18(2,14)15/h3-4,11H,1-2H3/b12-7+

InChI key

OOGAPDPPVHJYGJ-KPKJPENVSA-N

A cell-permeable thienylhydrazone analog that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5′ UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein.