Fn14 Antagonist, L524-0366

A Fn14 antagonist

Cat. No.: AUR10393

CAS Number: 951612-19-4

Documents:

SizePrice

25 mg

$ 275

Tags L524-0366 L5240366 Fn14 Antagonist CAS#951612-19-4 951612-19-4 Auroramedbiochem

Alternate Names

[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholin-4-ylmethanone

Appearance

Off-white solid

Formulation

N/A

CAS Number

951612-19-4

Molecular Formula

C13H13ClN4OS

Molecular Weight

308.78

Purity

≥98% by LCMS

Solubility

DMSO (25 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

MFCD15129559

PubChem CID

20973801

SMILES

C1CSCCN1C(=O)C2=CN(N=N2)C3=CC(=CC=C3)Cl

InChI

InChI=1S/C13H13ClN4OS/c14-10-2-1-3-11(8-10)18-9-12(15-16-18)13(19)17-4-6-20-7-5-17/h1-3,8-9H,4-7H2

InChI key

ZOBDTKWDYMRKPF-UHFFFAOYSA-N

L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM.