Cyclopamine-KAAD

A hedgehog signaling inhibitor

Cat. No.: AUR10229

CAS Number: 306387-90-6

Documents:

SizePrice

5 mg

$ 1675

Tags Cyclopamine-KAAD hedgehog signaling inhibitor CAS#306387-90-6 306387-90-6 Auroramedbiochem

Alternate Names

N-[2-(3\',6\',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2\'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4\'-yl)ethyl]-6-(3-phenylpropanoylamino)hexanamide

Appearance

Pale yellow solid

Formulation

N/A

CAS Number

306387-90-6

Molecular Formula

C44H63N3O4

Molecular Weight

698

Purity

>80% by HPLC

Solubility

DMSO or EtOH

Handling

Protect from air and light

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

16760383

SMILES

CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCC7=CC=CC=C7

InChI

InChI=1S/C44H63N3O4/c1-29-25-39-42(47(28-29)24-23-46-40(49)13-9-6-10-22-45-41(50)17-14-32-11-7-5-8-12-32)31(3)44(51-39)21-19-35-36-16-15-33-26-34(48)18-20-43(33,4)38(36)27-37(35)30(44)2/h5,7-8,11-12,15,29,31,35-36,38-39,42H,6,9-10,13-14,16-28H2,1-4H3,(H,45,50)(H,46,49)/t29?,31-,35?,36?,38?,39-,42?,43?,44?/m1/s1

InChI key

WDHRPWOAMDJICD-BWBMXWGBSA-N

Cell-permeable. Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner

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