Necrosulfonamide

A potent necroptosis inhibitor

Cat. No.: AUR10634

CAS Number: 432531-71-0; 1360614-48-7

Documents:

SizePrice

100 mg

$ 875

Tags Necrosulfonamide necroptosis inhibitor RIP3 kinase inhibitor CAS#432531-71-0 1360614-48-7 Auroramedbiochem

Alternate Names

E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide

Appearance

Dark yellow solid

Formulation

N/A

CAS Number

432531-71-0; 1360614-48-7

Molecular Formula

C18H15N5O6S2

Molecular Weight

461.5

Purity

>95% by HPLC

Solubility

DMSO (>5 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

gel pack

Shelf life

24 months

MDL number

N/A

PubChem CID

1566236

SMILES

COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]

InChI

InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+

InChI key

FNPPHVLYVGMZMZ-XBXARRHUSA-N

Necrosulfonamide is a potent necroptosis inhibitor. It blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.