Kir1.1 Inhibitor, VU591

A ROMK blocker

Cat. No.: AUR10532

CAS Number: 1222810-74-3

Documents:

SizePrice

25 mg

$ 225

Tags VU591 VU-591 potassium channel ROMK blocker CAS#1222810-74-3 1222810-74-3 Auroraedbiochem

Alternate Names

VU591; 6-nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole

Appearance

Light gray solid

Formulation

N/A

CAS Number

1222810-74-3

Molecular Formula

C16H12N6O5

Molecular Weight

368.3

Purity

≥98% by HPLC

Solubility

DMSO (100 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

44123657

SMILES

C1=CC2=C(C=C1[N+](=O)[O-])NC(=N2)COCC3=NC4=C(N3)C=C(C=C4)[N+](=O)[O-]

InChI

InChI=1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)

InChI key

ZQPXNYLXYNRFNP-UHFFFAOYSA-N

VU591 is a renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1.1 (IC50 = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. I